Probing microscopic cellular architecture in the mouse brain by oscillating gradient diffusion tensor imaging
نویسندگان
چکیده
the hippocampus showing the granular cell layer of the dentate gyrus (arrows) revealed by DTI contrasts at 160 Hz, which is not discernible at 0 Hz. Corresponding nissl-stained sections indicating the granular cell layer of the dentate gyrus (DG_gr) are shown for anatomical comparison. Bottom panel) Mean ADC in the DG_gr and a region within the CA1 subfield of the hippocampus plotted as a function of the gradient modulation frequency. Fig. 1: Frequency-dependent DTI contrasts in the mouse cerebellum. A-B) Comparison of ADC and DEC maps at 0 Hz (A,B) and 160 Hz (A’,B’). ADC at 160 Hz revealed enhanced contrasts between the molecular and granular cell layers (right), not seen with pulsed gradient DTI (left). C) Measured ADC as a function of frequency in the cerebellar molecular (CB_ml) and granular cell (CB_gr) layers. Probing microscopic cellular architecture in the mouse brain by oscillating gradient diffusion tensor imaging
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